Verruculogen Facts Sheet (main)

This mini website about Verruculogen was prepared by a student of BioInformatics, the Open University.

alternate names: Verruculogen

Tremorgenic mycotoxin. Potent inhibitors of Ca activated K(maxi K) channel

(from):. . A neurotoxin that blocks Ca²⁺-activated K⁺ channels. Also arrests cell cycle in M phase

Molecular formula C₂₇H₃₃N₃O₇  Molecular weight 511.6 

Gallagher, R. T.; Latch, G. C. M. (1977) Production of the tremorgenic
mycotoxins verruculogen and fumitremorgin B by Penicillium piscarium
Westling. Appl Environ Microbiol 33(3):730-731

(fromn:) Verruculogen, a potent tremorgen, and fumagillin, formerly used as a cytostatic drug, are mycotoxins found in Aspergillus fumigatus. Penicillium crustosum and Penicillium brevicompactum each produced the tremorgens roquefortine C and penitrem A. The mycotoxin standards library can be used to identify specific mold species in ambient air samples from environmental and occupational investigations.
 

about production of verruculogen  (J Gen Microbiol 1980 Apr;117(2):405-10)